Publications

(2020)

Brown, A. S., Sissons, J. A., Owen, J. G., & Ackerley, D. F. (2020). Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferase for Counter-Screening Antibiotic Candidates. ACS Infectious Diseases. 6(11). 2879-2886.

Copp, J. N., Pletzer, D., Brown, A. S., Van der Heijden, J., Miton, C. M., Edgar, R. J., Rich, M. H., Little, R. F., Williams, E. M., Hancock, R., Tokuriki, N., & Ackerley, D. F. (2020). Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections. mBio. 11(5). e02068-20

Calcott, M. J., Owen, J. G., & Ackerley, D. F. (2020). Efficient rational modification of non-ribosomal peptides by adenylation domain substitution. Nature Communications. 11(1). 4554

McCone, J., Somarathne, K. K., Orme, C. L., Hewitt, R. J., Grant, E. R., Hall, K. R., Ackerley, D. F., La Flamme, A. C., & Harvey, J. E. (2020). Total Synthesis and Bioactivity Studies of Fungal Metabolite (-)-TAN-2483B. Organic Letters. 22(24). 9427-9432

Storey, M. A., Andreassend, S. K., Bracegirdle, J., Brown, A., Keyzers, R. A., Ackerley, D. F., Northcote, P. T., & Owen, J. G. (2020). Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts. mBio. 11(2). e02997-19

Brown, A. S., Ackerley, D. F. & Calcott, M. J. (2020). High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor. Molecules. 25(20). 4666

Mowday, A. M., Copp, J. N., Syddall, S. P., Dubois, L. J., Wang, J., Lieuwes, N. G., Biemans, R., Ashoorzadeh, A., Abbattista, M. R., Williams, E. M., Guise, C. P., Lambin, P., Ackerley, D. F., Smaill, J. B., Theys, J. & Patterson, A. V. (2020). E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications. Theranostics. 10(23). 10548-10562

Sharrock, A.V., Mulligan, T.S., Hall, K.R., Williams, E.M., White, D.T., Zhang, L., Matthews, F., Nimmagadda, S., Washington, S., Le, K., Meir-Levi, D., Cox, O.L., Saxena, M.T., Calof, A.L., Lopez-Burks, M.E., Lander, A.D., Ding, D., Ji, H., Ackerley, D.F. & Mumm, J.S. (2020). NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation. bioRXiv. preprint

Sharma, J. K., Stevenson, L. J., Robins, K. J., Williamson, A. K., Patrick, W. M. & Ackerley, D. F. (2020). Methods for competitive enrichment and evaluation of superior DNA ligases.. Methods in enzymology. 644. 209-225

Chan-Hyams, J. & Ackerley, D. F. (2020). Protocol for evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative bacterial vector. MethodsX. 7. 100797

(2019)

Mowday, A.M., Lieuwes, N.G., Biemans, R., Guise, C.P., Ashoorzadeh, A., Zygouropoulou, M., Minton, N.P., Lambin, P., Ackerley, D.F., Smaill, J.B. & Dubois, L.J. (2019). Targeting the tumour microenvironment with anaerobic bacteria. Human Gene Therapy. 30(11). A50-A51

Williams, E. M., Sharrock, A. V., Rylott, E. L., Bruce, N. C., MacKichan, J. K., & Ackerley, D. F. (2019). A cofactor consumption screen identifies promising NfsB family nitroreductases for dinitrotoluene remediation. Biotechnology letters. 41(10). 1155-1162

Stevenson, L. J., Owen, J. G. & Ackerley, D. F.. (2019). Metagenome Driven Discovery of Nonribosomal Peptides. ACS chemical biology. 14(10). 2115-2126

Williams, E. M., Rich, M. H., Mowday, A. M., Ashoorzadeh, A., Copp, J. N., Guise, C. P., Anderson, R. F., Flanagan, J. U., Smaill, J. B., Patterson, A. V. & Ackerley, D. F. (2019). Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy. Biochemistry. 58(35). 3700-3710

Bracegirdle, J., Robertson, L. P., Hume, P. A., Page, M. J., Sharrock, A. V., Ackerley, D. F., Carroll, A. R. & Keyzers, R. A. (2019). Lamellarin Sulfates from the Pacific Tunicate Didemnum ternerratum. Journal of natural products. 82(7). 2000-2008