Publications
(2020)
. (2020). Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts. mBio. 11(2). e02997-19
. (2020). High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor. Molecules. 25(20). 4666
. (2020). E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications. Theranostics. 10(23). 10548-10562
. (2020). NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation. bioRXiv. preprint
. (2020). Methods for competitive enrichment and evaluation of superior DNA ligases.. Methods in enzymology. 644. 209-225
. (2020). Protocol for evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative bacterial vector. MethodsX. 7. 100797
. (2020). The indigoidine synthetase BpsA provides a colorimetric ATP assay that can be adapted to quantify the substrate preferences of other NRPS enzymes. Biotechnology Letters. 42(12). 2665–2671
. (2020). Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues. eLife. 9. e59081
. (2020). Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferase for Counter-Screening Antibiotic Candidates. ACS Infectious Diseases. 6(11). 2879-2886.
. (2020). Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections. mBio. 11(5). e02068-20
(2019)
. (2019). Targeting the tumour microenvironment with anaerobic bacteria. Human Gene Therapy. 30(11). A50-A51
. (2019). A cofactor consumption screen identifies promising NfsB family nitroreductases for dinitrotoluene remediation. Biotechnology letters. 41(10). 1155-1162
. (2019). Metagenome Driven Discovery of Nonribosomal Peptides. ACS chemical biology. 14(10). 2115-2126